http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2397955-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7aa001f3235c07b0298867908d45e21 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2000-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2119184710119e8c5cc2d0f49a644b1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3e251b7186e9bc55f7d22be7abad161 |
| publicationDate | 2001-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2397955-A1 |
| titleOfInvention | Method for pr-39 peptide mediated selective inhibition of i.kappa.b.alpha. degradation |
| abstract | The present invention provides both a method and means for regulating I.kappa.B.alpha. degradation, NF.kappa.B activity, and NF.kappa.B-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such I.kappa.B.alpha. and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with I.kappa.B.alpha. is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of I.kappa.B.alpha., a decrease of NF.kappa.B activity, and a down-regulation of NF.kappa.B-dependent gene expression. |
| priorityDate | 1999-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 450.