| abstract |
The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associate d nucleic acids, peptides, vectors, cells and isolates and assays. An enzyme that cleaves the .alpha.-secretase site of APP also is provided. The inventi on further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularl y useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease. |