http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2395652-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4741 |
| filingDate | 2002-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_658b2627a3b552d6889b7cf5bfbcc622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10d3f44ebfe8dc5a72754deed4d327c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d62317382cbd3c03a124be6d51bd5c79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0091c401b5a5fe68574594d9483321c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94edfb8cf668db57831d66f905c467b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b5294e2bb3874997343ac1d1397f7cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94f3019bde53714dee2d6f945df545e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d67e70f7aac7a1972faae9131fc64d88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66c8a2986ce4f83135833b5459084446 |
| publicationDate | 2003-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2395652-A1 |
| titleOfInvention | New derivatives of benzo[b]pyrano[3,2-h]acridin-7-one, process for preparing them, and pharmaceutical compounds containing them |
| abstract | The invention relates to novel compounds corresponding to formula (I) in which X and Y, which may be identical or different, each represent a hydrogen or halogen atom, or a mercapto, cyano or nitro group, alkyl, trihaloalkyl or trihaloalkylcarbonylamino, or a group of formula ORa, NRaRb, -NRaC (O) -T1, -OC (O) -T1, -O-T2-NRaRb, -O-T2-ORa, -NRa- T2-NRaRb, -NRa-T2-ORa or -NRa-T2-CO2Ra wherein Ra represents a hydrogen atony or an alkyl, aryl or arylalkyl group, Rb represents a hydrogen atom or an alkyl, aryl or arylalkyl group , or Ra and Rb together with the nitrogen atom carrying them a 5- to 6-membered heterocycle, T1 represents an alkyl, alkenyl, aryl or arylalkyl group or an alkylene chain substituted with a group -ORa or -NRaRb in which Ra and Rb are as defined above, T2 represents an alkylene chain, or X and Y, when in positions a together, form a methylenedioxy or ethylenedioxy group; R1 represents a hydrogen atom or an alkyl group; R2 represents a hydrogen atom, an alkyl group or a group ORa, NRaRb, -NRa-C (O) -T1, -OC (O) -T1, -O-T2-NRaRb, -O-T2-ORa, -NRa-T2-NRaRb, -NRa-T2-ORa or -NRa-T2-CO2Ra wherein Ra, Rb, T1 and T2 are as previously defined; R3 and R4, which may be identical or different, represent a hydrogen atom or an alkyl group; W represents a group of formula -CH (R5) -CH (R6) -, -CH = C (R7) -, -C (R7) = CH- or -C (O) -CH (R8) - in which R5 and R6, which may be identical or different, represent a group -W1-C (W2) -W3-T'1, -W4-C (W2) -T'1, -W1-S (O) n -W3-T1 or - W1-S (O) n-T1 wherein W1 is oxygen, sulfur or substituted nitrogen, W2 is oxygen or sulfur, W3 is oxygen, of sulfur or a substituted nitrogen atom, or a bond when T1 represents an alkenyl group, W4 represents a sulfur atom or a substituted nitrogen atom, T1 is as defined above, T'1 represents an alkenyl or arylalkyl group , or an alkylene chain substituted with a group - ORa or - NRaRb in which Ra and Rb are as defined above, n represents 1 or 2, and in the case where only one of the two groups R5 and R6 represents a group as defined previously, then the other of those groupings R5 or R6 represents a hydrogen atom or an optionally substituted hydroxy, alkoxy, alkylcarbonyloxy, arylcarbonyloxy, arylalkylcarbonyloxy or amino group, R7 represents a hydroxy group or an alkoxy group, or a -C (W2) -T1, -W1-C group (W2) -W3-T1, -W1-C (W2) -T1, -W1-S (O) n-W3-T1 or -W1-S (O) n-T1 in which W1, W2, W3, T1 and n are as defined above, R8 represents an alkoxy or alkylcarbonyloxy group. The invention also relates to the enantiomers, diastereoisomers and N-oxides compounds of formula (I), as well as their addition salts with a pharmaceutically acceptable acid or base. The compounds according to the invention are useful as medicaments for the treatment of cancers. |
| priorityDate | 2001-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.