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filingDate 2000-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2009-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_132546518245f505bc80565564a05cdf
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publicationDate 2009-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2395364-C
titleOfInvention Model animal with onset of collagen-induced arthritis
abstract The present invention provides a model animal with favorite onset of rheumatoid arthritis wherein the severity of arthritis reaches the maximum level and its onset ratio is a hundred percent, and a screening method of a remedy for rheumatoid arthritis by using the model animal. A mouse whose function of immunoglobulin Fc.gamma. receptor IIB gene is deficient on its chromosome and a wild-type collagen-induced arthritis-susceptible DBA/1J mouse are backcrossed six times or more, and a model mouse with favorite onset of rheumatoid arthritis is constructed. This model mouse with favorite onset of rheumatoid arthritis is immunized with bovine joint-origin type II collagen to develop collagen-induced arthritis.
priorityDate 1999-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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