| abstract |
Compounds of general formula (I) are useful in the treatment and prevention of .beta.3-related diseases including diabetes, obesity and hypertention wherei n R1 is hydrogen, halogeno, or hydroxyl; R2 is lower alkyl or benzyl; R3 is OR , halogeno, trifluoromethyl, lower alkyl, lower acyl, NR4R4', nitro, or cyano; R is hydrogen, lower alkyl, benzyl, or optionally substituted lower acyl; R4 a nd R4' are each independently hydrogen, lower alkyl, lower acyl, benzyl, or - SO2R5; R5 is lower alkyl or benzyl; W is oxygen, a secondary nitrogen atom (NH), or sulfur; and * represents an asymmetric carbon atom. |