| abstract |
Substituted 1,3,4-oxadiazole compounds reduce the levels of TNF.alpha. in a mammal. Typical embodiments are 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(1,3,4- oxadiazol-2-yl)ethyl]-5-methylisoindoline-1,3-dione and 2-[1-(3-ethoxy-4-methoxyphenyl)-2-(1,3,4-oxadiazol- 2-yl)ethyl]isoindoline-1,3-dione. The substituted 1,3,4-oxadiazole compounds include compounds of the formula: (see above formula I). |