| abstract |
Compounds of formula (I) and pharmaceutically acceptable salts thereof. As used in formula (I), and throughout the specification, the symbols have the following meanings: R1 and R2 are independently hydrogen, fluorine or alkyl; R3 is aryl or heteroaryl, R4 has various meanings; R5 is hydrogen or alkyl; m is an integer of 0 to 2; and n is an integer of 1 to 3. The compounds of formula (I) are protein kinase inhibitors and are useful in the treatment an d prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's diseases cardiovascular diseases, viral disease s and fungal diseases. |