| abstract |
Heterocyclic compounds represented by the following general formula [I] and pharmaceutically acceptable salts thereof: wherein R1 represents hydrogen or lower alkyl; R2 represents hydrogen, optionally substituted alkyl, etc.; R3 represents hydrogen, lower alkyl, etc.; A represents a single bond or >N- R5 (wherein R5 represents hydrogen or lower alkyl); B represents lower alkylene ; and Y represents optionally substituted aryl, etc. Because of having the effects of lowering blood glucose level, lowering blood lipid level, ameliorating insulin resistance and activating PPAR, these compounds are useful as hypoglycemics, hypolipidemics, insulin resistance-ameliorating agents, remedies for diabetes, remedies for complication of diabetes, agents of ameliorating impaired glucose tolerance, antiarteriosclerosis agents, antiobestic agents, anti-inflammatory agents, preventives and remedies for PPAR-mediated diseases and preventives and remedies for X syndrome. |