| abstract |
The present invention relates to the identification of a new family of CTL genes (Choline Transporter Like), in particular of hCTL1 and hCTL2, involved in the metabolism and / or transport of choline in cells such as intestinal tract cells, nerve cells, especially motor neurons, sensory neurons, neurons in the nucleus dorsal of the spinal cord and oligodendrocytes. The invention opens up new perspectives especially for the treatment of dysautonomia family, and Tangier's disease. More generally, identification CTL genes allow the development of new strategies for the treatment of diseases of the nervous system, especially diseases neurodegenerative, demyelinating, preferably Alzheimer's disease, Parkinson's, and Huntington's. |