| abstract |
The present invention is to provide a method to perform assays that efficiently and accurately can screen large numbers of cell populations producing variants of a molecule of interest. In a first aspect the inventio n relates to a method for high throughput screening (HTS) of a large populatio n of host cells for production of a molecule of interest, the method comprisin g the steps of: a) arranging the host cells in a spatial array so each positio n in the spatial array is occupied by one cell, b) cultivating the host cells under growth conditions suitable for HTS, c) assaying each array position fo r production of the molecule of interest, and d) selecting the cells from thos e positions where the molecule was produced, as determined in step c). |