http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2388660-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8fb5e79afb58766b8d510c76c4d5bee |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6478 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
filingDate | 1999-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_489cffcb246cf6f2a5233c8c4fd0f75d |
publicationDate | 2000-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-2388660-A1 |
titleOfInvention | Secretases related to alzheimer's dementia |
abstract | The invention is directed to methods of selecting secretases that cleave the amyloid precursor protein (APP) substrate, inhibiting production of the A.beta. peptide found in Alzheimer's Disease and treating Alzheimer's diseas e in patients. The invention also is directed tp a novel .beta.-secretase that produces the A.beta. peptide. One .beta.-secretase is a protein having a molecular weight of about 61, 81 or 88 kDa that cleaves an APP substrate. Another is a protease complex having a molecular between about 180 and 200 kDa, which, in one embodiment, contains the 61, 81, and 88 kDa proteins and, in another embodiment, contains proteins having a molecular weight of about 66, 60, 33 and 29 kDa. Another .beta.-secretase has a molecular weight betwe en about 50 and 90 kDa. |
priorityDate | 1998-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 460.