| abstract |
Compounds represented by general formula (I), wherein basic groups are attached to the 3-position of the piperidine ring either directly or via various groups, having an integrin .alpha.v.beta.3 antagonism. These compoun ds are useful in treating or preventing cardiovascular diseases, diseases in association with angiogenesis, cerebrovascular diseases, cancer and metastas is thereof, immune diseases, bone diseases, etc., wherein A represents an optionally substituted heterocyclic group containing at least one nitrogen atom, etc.; D represents a bond, >NR4, O, etc.; Z represents CH or N; R7 and R8 represent each OH, etc.; Q represents >C=O, etc.; R9 represents H, etc .; J represents a bond or alkylene; R10 represents optionally substituted OH, etc .; R11 represents H, etc.; m is from 0 to 5; n is from 0 to 4; p is 3 or 4; and q is from 0 to 3. |