| abstract |
The present invention relates to compositions of chondrocyte cells, in particular human cells, and methods for their preparation and their uses. The invention more particularly describes the production of suspensions of autologous human chondrocytes, using recombinant enzymes and / or media compatible with pharmaceutical use. The invention also describes methods and compositions for freezing chondrocytes, especially in the absence of DMSO. The chondrocytes produced can be used in vivo to restore affected cartilage structures, such as post-traumatic cartilage defects or dissecting osteochondritis of the knee or, more generally, for the treatment and repair of clinically significant cartilage defects, including articular cartilage. |