http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2384021-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e0c9decd89e0ec3c2815631e084dd40 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96425 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 |
| filingDate | 2000-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d95c78e155718f8ba50061b740956bfb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4c12fa9d1fa728669a717fc5f6661fc |
| publicationDate | 2001-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2384021-A1 |
| titleOfInvention | Compositions for the detection of enzyme activity in biological samples and methods of use thereof |
| abstract | The present invention provides for novel reagents whose fluorescence increas es in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated to two fluorophores su ch that the fluorophores are located opposite sides of a cleavage site. When th e folded peptide is cleaved, as by digestion with a protease, the fluorophores provide a high intensity fluorescent signal at a visible wavelength. Because of their high fluorescence signal in the visible wavelengths, these protease indicators are particularly well suited for detection of protease activity i n biological samples, in particular in frozen tissue sections. Thus this invention also provides for methods of detecting protease activity in situ i n frozen sections. |
| priorityDate | 1999-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 413.