Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-93 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
filingDate |
2000-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03d2c6c017dcfa4f097bfffc76f2e8e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_187f6089bc5790522bead906ec615ce3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f98cdcd66dbff53d187407fef894530b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf3029effe33892bd477de10f0b202be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0743dc10bb693073817005ea56f7bfd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_864ae3426f4bf3dd984bbb163ec35384 |
publicationDate |
2001-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2378661-A1 |
titleOfInvention |
Attenuated human-bovine chimeric parainfluenza virus (piv) vaccines |
abstract |
Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an anti-PIV immune respons e. Also provided are isolated polynucleotide molecules and vectors incorporatin g a chimeric PIV genome or antigenome which includes a partial or complete hum an or bovine PIV "background" genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV. Chimeric human-bovine PIV of the invention include a partial or complete "background" PIV genome or antigenome derived from or patterned after a huma n or bovine PIV virus combined with one or more heterologous gene(s) or genome segment(s) of a different PIV virus to form the human-bovine chimeric PIV genome or antigenome. In certain aspects of the invention, chimeric PIV incorporate a partial or complete human PIV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a bovine PIV, whereby the resultant chimeric virus is attenuated by virtue of host-range restriction. In alternate embodiments, human-bovine chimeric PIV incorporate a partial or complete bovine PIV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human PIV gene that encode a human PIV immunogenic protein, protein domain o r epitope, for example encoded by PIV HN and/or F glycoprotein gene(s) or geno me segment(s). Human-bovine chimeric PIV of the invention are also useful as vectors for developing vaccines against other pathogens. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric PIV of the invention to yield desired phenotypic and structural effects. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8841433-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8715922-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10519517-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9593386-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9834824-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9376726-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11162148-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10167524-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10287640-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9567653-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11220718-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8927206-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9803252-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9334543-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9944997-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722341-B2 |
priorityDate |
1999-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |