| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634d7355c2673489b2f4f800541770bb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0356 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-723
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
2000-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_724e1c382328d859c8b6cca44a914a34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d6384b8d8c60758ed2cdc8b26e9e488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76178b0df838363ca7d7c7d5ad65e1a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a456d6c2f0a160c2a65c1140ba4123d |
| publicationDate |
2001-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2375943-A1 |
| titleOfInvention |
Corticotropin releasing factor receptor 2 deficient mice and uses thereof |
| abstract |
The present invention provides transgenic mice deficient in corticotropin releasing factor receptor 2. CRFR2 mutant mice are hypersensitive to stress, and display increased anxiety-like behavior. Mutant mice had normal basal feeding and weight gain, but exhibited decreased food intake following food deprivation. Intravenous UCN has no effect on the mutant mice, but causes decreased arterial pressure in control animals. Deficiency in CRFR2 results in a significant increase in urocortin mRNA in the rostral region of the Edinge r Westphal, and a significant increase in CRF mRNA in the central nucleus of t he amygdala. These results demonstrate that CRFR2 mutant mice, as opposed to CRFR1 mutant mice, have an increased sensitivity to stress and display anxie ty- like behavior. |
| priorityDate |
1999-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |