| abstract |
The present invention relates to new methods and compositions for the pharmacological regulation of the expression of transgenes. It concerns more particularly a composition comprising: (a) a first element comprising a nucleic acid of interest under the control of an inducible promoter including a response element to a PPAR and a transcriptional promoter minimal, and (b) a second element comprising a nucleic acid encoding a PPAR under the control of a transcriptional promoter, with a view to their use simultaneous, separate or spaced over time. The invention relates to the use of these compositions and methods in the experimental fields, clinical, therapeutic or diagnostic. |