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filingDate 2000-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2375108-A1
titleOfInvention Array cytometry
abstract A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silico n oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spati al control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules an d the manipulation of array shape and size. The present invention enables samp le preparation and handling for diagnostic assays and biochemical analysis in a n array format, and the functional integration of these operations. In additio n, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cell s on semiconductorsurfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination.
priorityDate 1999-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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