| abstract |
Compounds which are useful as drugs because of not only having a high metalloproteinase inhibitory activity but also being capable of remarkably improving the medicinal activities (for example, oral absorbability) and biological activities in vivo; intermediates in the production thereof; and a process for producing the same. Compounds represented by general formula (I) wherein R1, R2, R3, R5, R6, R7 and R8 represent each hydrogen, etc.; and R4 represents alkyl, etc.; or salts thereof are useful as medicinal and/or veterinary compositions, in particular, metalloproteinase inhibitors inhibiting matrix metalloproteinases and/or tumor necrosis factor-.alpha. (T NF- .alpha.) convertase. |