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filingDate 2000-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2371220-A1
titleOfInvention Promoter-transactivator system for inducible high-level mammalian gene expression with the option of cell growth control
abstract A promoter-transactivator system achieves regulated high-level gene expressi on in proliferation-controlled mammalian cells. The novel composite promoter contains constitutive enhancer elements that allows a basal expression level as high as the levels achieved with a very efficient viral promoter. In addition, the promoter encodes sequences that are bound by a transactivator whose activity can be regulated. By the simple addition of medium supplement s expression levels can be achieved above those from the conventional promoter .
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