| abstract |
The invention relates to the compounds of formula (I) that their salts with mineral or organic acids, their solvates and / or their hydrates, having a high affinity and high selectivity for human NK1 receptors the Substance P. The invention also relates to their method of preparation, the intermediate compounds of formulas (IV) (see formula I) in which: Ar represents a phenyl monosubstituted or disubstituted by a halogen atom or a (C1-C3) alkyl; E represents a protecting group; R1 represents a chlorine atom, a bromine atom, a (C1-C3) alkyl or trifluoromethyl; and Y represents a methyl, phenyl, tolyl or trifluoromethyl; useful for their preparation, the compositions pharmaceutical products containing them and their use for manufacture of medicaments for treating any pathology where Substance P and / or human NK1 receptors are involved. |