| abstract |
New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8-carbo and 8-oxo tropanes having 6- or 7--hydroxyl or ketone substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter. The tropane analogs of the present invention have the following structural formula: (see formula I or II or III) wherein: R1 = COOR7, COR3, lower alkyl, lower alkenyl, lower alkynyl, CONHR4, or COR6 and is .alpha. or .beta.; R2 = O, is a 6- or 7- substituent; X = NR3, CH2, CHY, CYY1, CO, O, S; SO, SO2, NSO2R3, or C=CX1Y with the N, C, O or S atom being a member of the ring; X1 = NR3, CH2, CHY, CYY1, CO, O, S; SO, SO2, or NSO2R3; R3= H, (CH2)n C6H4Y, CHCH2, lower alkyl, lower alkenyl or lower alkynyl; Y and Y1 = H, Br, C1, I, F, OH, OCH3, CF3, NO2, NH2, CN, NHCOCH3, N(CH3)2, (CH2)n CH3, COCH3, or C(CH3)3; R4 = CH3, CH2CH3, or CH3SO2; R6 = morpholinyl or piperidinyl; Ar = phenyl-R5, naphthyl-R5, anthracenyl-R5, phenanthrenyl-R5, or diphenylmethoxy-R5; R5 = H, Br, C1, I, F, OH, OCH3, CF3, NO2, NH2, CN, NHCOCH3, N(CH3)2, (CH2)n CH3, COCH3, C(CH3)3, 3,4-diCl, 3,4-diOH, 3,4-diOAc, 3,4-diOCH3, 3-OH-4-Cl, 3-OH-4-F, 3-Cl-4-OH, 3-F-4-OH; n = 0, 1, 2, 3, 4 or 5; R7= lower alkyl; and when X = N, R1 is not COR6. |