abstract |
Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility in a therapeutically effective amoun t, wherein the drug is present in the form of solid particles, about 25 % to 10 0 % by weight of which are smaller than 1 .mu.m. The compositions are useful i n treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorde rs and have particular advantages where rapid onset of therapeutic effect is desired. |