| abstract |
In a preferred aspect of the invention, the upstream sequences of the TIGR protein encoding sequence can be used to diagnose a sensitivity to steroids and a risk for glaucoma or ocular hypertensive disorders. Methods, kits, and nucleic acids containing polymorphisms, base substitutions, or base additions located within the upstream region and within protein-encoding regions of the TIGR gene are also provided. The upstream sequences disclosed, including the TIGR promoter regions and those regions possessing functional characteristics associated with or possessed by the TIGR gene 5' regulatory region, can also be used to generate cells, vectors, transgenic animals, and nucleic acid constructs useful in a variety of diagnostic and prognostic methods and kits as well as therapeutic compounds, compositions and methods. |