abstract |
The present invention provides drugs and kits for treating osteoarthritis using an estrogen agonist/antagonist. The estrogen agonist/antagonist may be a compound of the formula: <see formula I> wherein A is CH2 or NR; B, D and Z are each CH or N; Y is a ring (e.g., phenyl); Z1 is a bridge; G is a (cyclic)amino; and a is 0, 1 or 2. |