| abstract |
Remedies for pain which contain as the active ingredient compounds having bo th of an opioid .mu. receptor agonist activity and a dopamine D2 receptor antagonist activity. The compounds having both of these activities exert a potent morphine-like analgetic effect but cause no mental dependency. Moreover, these compounds can regulate side effects. In particular, novel compounds represented by general formula (I) and pharmacologically acceptabl e salts thereof have both of the opioid .mu. receptor agonist activity and the dopamine D2 receptor antagonist activity and are useful as remedies for pain with regulated side effects. |