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Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2512d10b0d980376e6b8a2e88d0530e9 |
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-24043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-24143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-21
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 |
| filingDate |
1999-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_193792b87c925bd36c8aec39b6326769
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_996b12954d152b76128bef3d3acb6e9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_024ea252c73bd15bdb622fea49fc8905 |
| publicationDate |
2009-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2354024-C |
| titleOfInvention |
A recombinant vector expressing multiple costimulatory molecules and uses thereof |
| abstract |
The present invention is a recombinant vector encoding and ex-pressing at least three or more costimulatory molecules. The recombi-nant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimula-tory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic mi-cro-organisms, and in providing host cells, including dendritic cells an d splenocytes with enhanced antigen-presenting functions. |
| priorityDate |
1998-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |