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filingDate 1999-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c597862794235fa765c35cc57ea9259
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publicationDate 2000-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2353643-A1
titleOfInvention Methods for producing selected interstrand cross-links in chromosomal nucleic acids and applications thereof
abstract The invention provides methods and means for generating interstrand cross- links in nucleic acid at certain specific locations in said nucleic acid. Sa id certain specific locations in said nucleic acid can be selected from other locations through hybridising nucleic acid present in said selected location with complementary nucleic. In one aspect the invention provides a method fo r providing at least one selected sequence in a nucleic acid with interstrand cross-links comprising hybridising at least one selected single strand sequence with a complementary single strand nucleic acid wherein said select ed sequence or said complementary nucleic acid or both comprise a cross-linking agent. The means and methods of the invention may be used in and beneficial for a wide variety of applications, such as the generation of nucleic acid probes and the treatment of diseases such as cancer.
priorityDate 1998-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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