http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2353082-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbadc41aa91592752369d88100f96411 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2845 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 1999-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_014c7be474ff9ca63d8d39126f878cba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dc3d68e05221f26031596308d044e13 |
| publicationDate | 2000-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2353082-A1 |
| titleOfInvention | Modified antibodies and antibody fragments with increased duration of activity |
| abstract | Modified antibodies with improved pharmacokinetic properties are disclosed. The antibodies bind to one or more human integrin receptors selected from the group consisting of GPIIb/IIIa, .alpha.v.beta.3 and Mac-1, and comprise one to about six organic moieties which are covalently bonded to specific sites on the antibodies. The organic moieties can each independently be a hydrophilic polymeric group, a fatty acid group, a fatty acid ester group, a lipid group or a phospholipid group. Also disclosed is a method of treating a human with a disease or disorder in which cells expressing GPIIb/IIIa,.alpha.v.beta.3 and/or Mac-1 play a pathophysiological role. The method comprises administering an effective amount of one or more antibodies of the invention to a human in need thereof. |
| priorityDate | 1998-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 260.