| abstract |
This invention is related to new oral pharmaceutical dosage forms comprising a proton pump inhibitor, i.e. a H+, K+ -ATPase inhibitor, a gastric antisecretory prostaglandin analogue compound, and optionally an additional drug such as a calcium channel blocking agent, especially for use in the treatment and prophylaxis of gastrointestinal disorders. More specifically t he invention is related to new dosage forms comprising omeprazole and misoprostol. The invention is also related to a combination of the three categories of drugs, i.e. the H+, K+ -ATPase inhibitor, the gastric antisecretory prostaglandin analogue, and the calcium channel blocking agent . Furthermore, the invention refers to a method for the manufacture of the described dosage forms and their use in medicine, as well as blister packs comprising these medicaments. |