| abstract |
The invention relates to a transport system conjugate serving as transmembrane transport system, consisting of at least one pharmaceutically and/or cosmetically active compound, said compound being modified in such a way that it contains at least one of the substituents of formula (I) -y-(NH-CnH2n-NH)r-C(O)-R and at least one Y bonded substituent of formula (II) and/or (III), wherein Y represents a radical of an amino acid originally having at least 3 reactive groups or a radical of 2 or 3 amino acids bonded to each other originally having at least 3 reactive groups selected from amino (-NH2) and/or carboxyl [-C(O)OH], or a trivalent radical of a trisamin with 2-8 C atoms, CnH2n -CH2CH2CH2- or -CH2CH2-, preferably -CH2CH2-, r represents zero or one, preferably 1, R-C(O) represents the radical of a saturated, monounsaturated or polyunsaturated, optionally substituted (C4-C24) fatty acid, R1 represents hydrogen or alkyl with 1, 2, 3 or 4 C atoms, preferably hydrogen or methyl, preferably hydrogen, m represents a whole number from 3 to 8, preferably 4, 5 or 6 and p represents 1, 2 or 3, preferably 1. The invention also relates to the utilization of said systems in the production of therapeutic agents for topical and transdermal applications, especially for dermatological and cosmetic applications or systemic drugs. |