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filingDate 1999-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2352483-A1
titleOfInvention Pharmaceutical aerosol composition containing hfa 227 and hfa 134a
abstract In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler to target specific regions of the respiratory tract. Moreover the fine particle dose (FPD) of the active ingredient in the composition increases by reducing the metering chamber volume.
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Total number of triples: 31.