| abstract |
The invention relates to novel compounds of formula (I): (see formula I) in which p represents an integer between 0 and 6 inclusive; n represents a integer from 0 to 6 inclusive; R1 and R2, identical or different, represent independently of one another a hydrogen atom or an alkyl group, aryl or arylalkyl, or R1 and R2 together with the nitrogen atom the gate, a saturated monocyclic or bicyclic system of 3 to 10 members; X represents an oxygen or sulfur atom, group -CH = CH-, a group methylene, a group -HC = NO- or a group -O-CH2-CH = CH- in which oxygen atom is connected to the Y group; and Y represents a aryl, heteroaryl, arylalkyl, heteroarylalkyl, -C (O) -A or -C (S) -AT in which A represents an alkyl, aryl or heteroaryl group, arylalkyl, heteroarylalkyl or a group NR3R4 in which R3 and R4, which are identical or different, each represents a hydrogen atom or an alkyl group, aryl or arylalkyl, or R3 and R4 together with the nitrogen atom the door, a monocyclic or bicyclic C3-C10 system. The invention is also directed the optical isomers of the compounds of formula (I), as well as their addition salts has a acid or a pharmaceutically acceptable base. The compounds according to the invention are useful as medicaments for the treatment of neuropathologies associated with cerebral aging, the mood, of pain and smoking cessation. |