http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2346436-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 |
| filingDate | 1999-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45cac683416f0f595010e8d0b6216a68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f18319baed3548dc00911a81a9426e46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4255e48816ef80c8cc2f3ae7eb2eec60 |
| publicationDate | 2000-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2346436-A1 |
| titleOfInvention | N-(imidazolylalkyl)substituted cyclic amines as histamine-h3 agonists or antagonists |
| abstract | The present invention discloses novel N(imidazolylalkyl)-substituted cyclic amine compounds of Formula (I), wherein R1 is selected from the group consisting of H,OCO-R7, andCO2R7 with R7 being a substituted or unsubstituted alkyl or aryl, the substituents on said substituted alkyl or aryl being selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, heterocyclic and halogen; R2 is selected from the group consisting of H, hydroxyl or halogen; G is spacer moiety selected from the group consisting of a C3-C7 straight chain alkyl, a C2-C7 alkene or a C2-C7 alkyne, with said straight chain alkyl, alkene or alkyne being optionally substituted with one or more R7 groups; and T which represents a cyclic amine is a ring moiety selected from the group consisting of a, b, c or d, wherein n is an integer for 0-3, and R3, R4, R5 and R6 can be the same or different with the proviso that any two of said R3, R4, R5 and R6 can be bound to the same or different carbon atom of ring T, with said R3, R4, R5 and R6 being independently selected from the group consisting of H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkenyl, substituted or unsubstituted C1-C6 alkynyl, aryl, aralkyl, alkylaryl, cycloalkyl, heterocyclic,C-O- R8,C(=O)R8, CO2R8, OC(O)R8, NH2,NHR8, N(R8)2, NR8R9, SR8, SO2R8, S(O)R8, OH,OR8, CH2OR8, CH2NH2, CH2N(R8)2, CH2NHR8, CH2SR8, C(O)-NHR8, C(O)NR8R9, CN,NO2, NR8-CO-, C(NH)-NR8, C(=NR8)NR9, NR8-C(NH)-, NHR8(CO)NHR9, (O-CR8-CR8-O)-, CX(R8)2, CX2R8, CX3,OCX3, N(R8)-S(O)R9, N(R8)-SO2R9, (=O), (=NH-OR8), C(=S)R8,NCR8, NOR8,NR8R9-SO2-NR8R9, OPO2R8, P+(R8)3X,SO3H, fused heteroaryl, and (=CR8) wherein R8 and R9 are independently H or C1-C6 alkyl, aryl, aralkyl, alkylaryl, cycloalkyl or heterocyclic, and X is a halogen which have excellent histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such cyclic amines as well as methods of using them to treat allergy, inflammatory and CNS-related diseases. |
| priorityDate | 1998-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 196.