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filingDate 1999-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2010-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2344061-C
titleOfInvention Crosslinking of bioprosthetic material to mitigate post-implantation calcification
abstract A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of: A) fixing the tissue; B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a cross-linking agent; C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto); and D) subjecting the bioprosthesis to terminal sterilization.
priorityDate 1998-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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