| abstract |
Apoptosis inducing agents which contain as the active ingredient tetrocarcin derivatives represented by general formula (I) or salts thereof. These agents are useful as drugs for preventing and/or treating diseases caused by the accelerated expression of proteins of the Bc1-2 family such as cancer and AIDS; wherein <u>---</u> represents a single or double bond; j and k are each 0 or 1; R1 to R3, R7 to R10 and R14 represent each hydrogen, lower alkyl, etc.; R4, R11, R12, R13 and R15 to R18 represent each hydrogen, hydroxy, lower alkyl, etc.; R5 and R6 represent each hydrogen, hydroxy, lower alkyl or (B) (wherein R32 represents formyl, etc.; and R33 to R35 represent each hydrogen, hydroxy, lower alkyl, etc.); and R19 represents hydroxy, lower alkoxy, lower alkanoyloxy, etc. |