| abstract |
An adenovirus complex including a complex of a cationic molecule and of an adenovirus having at least one polyalkalene glycol polymer bound thereto. The polyalkalene glycol polymer includes, but is not limited to, polyethylene glycol, methoxypolyethylene glycol, polymethylethylene glycol, polyhydroxypropylene glycol, polypropylene glycol, and polymethylpropylene glycol. Molecular weights for the polymer range from 200 to 20,000 Daltons, with 2000 to 12,000 Daltons being preferred. The adenovirus is a preferably recombinant adenoviral vector such as a recombinant viral vector containing a transgene. The polymer is bound, directly or indirectly, to the virus particle by covalent or noncovalent means. The cationic molecule is preferably a cationic polymer, such as DEAE-Dextran, or a cationic lipid. A composition containing the adenovirus complex and a carrier is also disclosed. |