| abstract |
The present application provides an attenuated gram-negative cell comprising a SPI2 gene locus wherein at least one of the effector gene, the chaperon gene or the secretion apparatus gene is inactivated. The present application also provides carriers comprising these attenuated gram-negative cells, methods of preparing such cells and carriers as well as methods of using such cells and carriers in the treatment of a disease related a microorganism, the treatment of a tumour and/or for the presentation of an antigen to a host. |