| abstract |
The invention provides isolated nucleic acid compounds encoding polypeptides and fragments thereof, said polypeptides being related to the human TGF.beta. latent binding protein (hLTBP) family. This invention also provides vectors and transformed heterologous host cells for expressing said polypeptides, a method of using said nucleic acids and polypeptides for inhibiting TGF.beta. dependent activities in vitro or in vivo, as well as pharmaceutical compositions comprising said nucleic acids or polypeptides. Also provided are assays used to identify compounds which bind to said polypeptides. |