| abstract |
The present invention relates to disubstituted bicyclic heterocycles of general formula R a - Het- B- Ar - E ,(I) wherein R a, Ar, B, Het and E are defined as in claim 1, the tautomers, stereoisomers, the mixtures thereof, the salts thereof and their preparation, as well as that of the pharmaceutical com-positions containing the pharmacologically active compounds, and their use. The compounds of the above general formula I wherein E denotes a cyano group are valuable intermediates for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein E denotes a R b NH-C(=NH) group have valuable pharmacological properties, particularly a throm-bin-inhibiting action and the effect of prolonging the thrombin time. |