| abstract |
The present invention provides a method of obscuring immune recognition of a transplant by a host mammal by encapsulating tissue suitable for use in a transplant within a hydrogel matrix, wherein the hydrogel matrix comprises gelatin, dextran, at least one nitric oxide inhibitor, and an effective amount of polar amino acids. The matrix binds to the cell surface proteins of the tissue and obscures recognition of the tissue by high affinity antibodies produced by the recipient of the transplant. |