Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30ec445f5a123373ceecff2fe8a4dc11 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-11013 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
1999-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13577904e537ed137bc14ff3902cb8fd |
publicationDate |
1999-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2329247-A1 |
titleOfInvention |
Amino-modified ribozymes |
abstract |
The invention relates to ribozymes modified to improve their stability, methods for producing such enzymes and the use of the modified enzymes in methods such as therapeutic treatment. In particular, a typical ribozyme according to the invention includes a modified ribozyme, wherein three or more pyrimidine nucleotides in said ribozyme are modified at the 2'-position, wherein said pyrimidine nucleotides are modified to 2'-amino pyrimidine nucleotides and said ribozyme exhibits improved stability to RNAse degradation and exhibits 85 % or more catalytic activity of the unmodified ribozyme. |
priorityDate |
1998-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |