Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
filingDate |
1999-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c45a3e72399c7969e27b8d4ff9be1f73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60ae1ae2578d4ce379d972c1bccb1812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_914d227718790a491334a7b62a4071e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1621d5e68ee10df9e2115f55b4ac9453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10df5e3eb893b8c0afbb6d99d7dd0a04 |
publicationDate |
1999-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2320260-A1 |
titleOfInvention |
Method of inhibiting membrane-type matrix metalloproteinase |
abstract |
The invention is a method of inhibiting the activity of membrane-type matrix metalloproteinase (MT-MMP) in biological systems. Accordingly, the invention permits the treatment of medical conditions in mammals that are characterized by MT-MMP activity, and especially those conditions characterized by excessive MT-MMP activity. The method employs a tetracycline compound, preferably a non-antimicrobial tetracycline, and more preferably 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) or 6-.alpha.-deoxy-5-hydroxy-4-de(dimethylamino)tetracycline (CMT-8) to inhibit the MT-MMP activity. |
priorityDate |
1998-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |