| abstract |
The invention relates to novel tetracyclic analogues of camptothecin of formula (1), their methods of preparation, their application as drugs and pharmaceutical compositions the container. Said analogues, of which in particular 3-hydroxy-3- (4-oxo-4,6-dihydroindolizino [1,2-b] quinolin-2-yl) pentanoic, exhibit biological activity potent inhibition of topoisomerase I and / or topoisomerase II. |