| abstract |
There is disclosed a method of reducing susceptibility of cells to infection by a retrovirus, comprising contacting the cells with an amount of a CD40 binding protein effective to reduce the expression of the chemokine receptor CCR5, and/or induce a post-entry block of the replication of the retrovirus. The method is useful in treating individuals infected with, or at risk of being infected with, HIV. CD40 binding proteins include CD40 ligand, monoclonal antibodies that specifically bind CD40, and combinations thereof. CD40 binding proteins may also be used in combination with other cytokines, including GM-CSF, IL-2 and IL-15. |