http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2312362-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3873abaff397acbfffa1595a12cfef41 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 1998-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c226996a3188a0f7cf2d7f1642637b77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfa22e2425b90e061a6b000567a0f093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_090e81fdc04e9dbcd7808c883d9dfcb1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9840cd27c911353d40f28294d595d4c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e94a99c259bded530e1f777359a6b6d |
| publicationDate | 1999-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2312362-A1 |
| titleOfInvention | Method for identifying agonists and antagonists of dna replication using an in vitro mammalian dna replication system |
| abstract | The present invention relates to an in vitro mammalian DNA replication system and to a method for identifying agonists and antagonists of DNA replication. The method comprises contacting in vitro a plasmid with a mixture comprising nuclear or cytoplasmic extracts from HeLa cells, the drug and a mixture of nucleotides, assessing the stimulation or the inhibition of initiation of DNA replication and the elongation of nascent DNA produced by the drug, and identifying the essential structures of the drug by quantitative structureactivity relationship (QSAR) analysis deriving relationships between the structural features of the drug and biological responses produced by the binding of the drug to the target receptor. The plasmid has a target receptor and comprises a specific mammalian origin of DNA replication. |
| priorityDate | 1997-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.