| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27155ed29f9b0bfa281f4b21b26d709a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 |
| filingDate |
1998-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f79156032582fe558a030ccb430b1fb8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dc3e6490e2acdf3c0462e3f8abb3a56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5bae8f8afe17c19c54f2b26b2043b1f |
| publicationDate |
2009-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2312004-C |
| titleOfInvention |
Site-specific preparation of polyethylene glycol-grf conjugates |
| abstract |
A method is described for the site-specific preparation of hGRF-PHG conjugat es containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or N.alpha., characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention or diagnos is of growth hormone deficiency, are also an object of the present invention. |
| priorityDate |
1997-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |