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filingDate 1998-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84a26a970c3c71a956e9228819ffd2d6
publicationDate 2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2309326-C
titleOfInvention Pharmaceutical compositions containing cyclodextrins and taxoids
abstract A process for the preparation of rapidly soluble products for pharmaceutical use is provided. The process comprises the following steps: dissolving in ethanol a taxoid or a salt, or a hydrate, or a solvate thereof; adding to the solution a lyophilized solid cyclodextrin derivative; and evaporating the solvent and drying to obtain a solid, which comprises the taxoid as the active ingredient and the cyclodextrin derivative. The weight ratio of taxoid:cyclodextrin derivative ranges between 1:25 and 1:400. The taxoid is selected from the group consisting of paclitaxel and docetaxel, and the cyclodextrin derivative is selected from the group consisting of acetyl-y-cyclodextrin and hydroxy-propyl-.beta.-cyclodextrin. When hydroxy-propyl-p-cyclodextrin is used, the taxoid can be only docetaxel in a 1:25 to 1:100 taxoid:cyclodextrin weight ratio.
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