| abstract |
Compounds represented by formula (I), wherein A is a 5 or 6-membered unsaturated heterocyclic ring containing at least one N atom; B is (a), NO2, N(R2)2, X2 is O, NH, NR, CH2, CHR or CR2, each R individually is alkyl, cycloalkyl, aryl, alkaryl and aralkyl, each R2 individually is H, alkyl, cycloalkyl, aryl, alkaryl, and aralkyl; Y is a halogen; alkythio group or nitrogenous moiety, are useful for activating Cl- secretion, and can be used for treating cystic fibrosis. |