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filingDate 1998-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9db5c113b5cb23fe36026e5c14e39982
publicationDate 1999-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2305528-A1
titleOfInvention Methods and compositions for reducing bacterial tolerance of disinfectants and organic solvents
abstract The invention relates to methods and compositions for manipulating bacterial resistance to non-antibiotic antibacterial compositions, disinfectants and organic solvents. The invention provides methods for rendering bacterial cells susceptible to non-antibiotic antibacterial compositions. Also provided are methods to reduce the selection of bacterial mutants having a multiple antibiotic resistance phenotype by non-antibiotic antibacterial compositions. The invention also provides methods for testing the ability of non-antibiotic antibacterial compositions to select for or induce a multiple antibiotic resistance phenotype in bacteria. Also provided are methods for increasing or decreasing bacterial tolerance to organic solvents by increasing or decreasing the activity of bacterial organic solvent efflux pumps. Compositions useful in the foregoing methods are also provided.
priorityDate 1997-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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